tag:blogger.com,1999:blog-3293839544812203654.post6535135322176884629..comments2024-02-24T14:57:51.680-08:00Comments on Valtsu's: Health Benefits of GlycineVladimir Heiskanen (Valtsu)http://www.blogger.com/profile/15561977841529110781noreply@blogger.comBlogger28125tag:blogger.com,1999:blog-3293839544812203654.post-56140461459044846892017-12-07T01:04:29.028-08:002017-12-07T01:04:29.028-08:00This is the first time i read this type of blog......This is the first time i read this type of blog...Thanks for sharing this blog..Shanayahttps://www.vitasave.ca/noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-33871543079771282892017-10-24T08:11:07.831-07:002017-10-24T08:11:07.831-07:00Could you take a Taurine and Glycine supplement a...Could you take a Taurine and Glycine supplement at the same time or would they cancel out each one's benefit?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-70702664961069740352017-04-10T04:43:58.082-07:002017-04-10T04:43:58.082-07:00Thank you for sharing great thoughts here. Indeed,...Thank you for sharing great thoughts here. Indeed, amino acids are beneficial in lots of ways. <br />Morrisperthttp://www.morrispert.com/noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-26057724499095898422017-03-10T23:17:37.741-08:002017-03-10T23:17:37.741-08:00Hi Anonymous,
That was a quote by biologist Ray P...Hi Anonymous,<br /><br />That was a quote by biologist Ray Peat. It's not a citation from the actual paper, therefore the [square brackets]. :-)Vladimir Heiskanen (Valtsu)https://www.blogger.com/profile/15561977841529110781noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-52181599585706809832017-03-10T22:48:59.107-08:002017-03-10T22:48:59.107-08:00Hi, I didn't find the key line shown in this s...Hi, I didn't find the key line shown in this study<br />Respond to molenaara@hotmail.com if possible<br /><br />[x] Trends Biochem Sci. 2014 Apr;39(4):191-198. Serine and glycine metabolism in cancer. Amelio I, Cutruzzolá F, Antonov A, Agostini M, Melino G. [Ray Peat: "When tumors aren't getting enough sugar and fat, they cause proteins to be broken down, and glutamine, glycine, and serine can be used for energy. But when glycine is present in the diet, it has various anti-tumor effects."]<br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-61040041829421349872016-09-09T09:39:57.796-07:002016-09-09T09:39:57.796-07:00Dr Anthony Samsel's extensive research found t...Dr Anthony Samsel's extensive research found that gelatin is contaminated with glyphosate, which in fact blocks the uptake of glycine, so eating gelatin could reduce glycine in our body. See https://www.youtube.com/watch?v=BPhfJx0o38obrothersunhttps://www.blogger.com/profile/02237494515012542631noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-41274636891993237972016-07-02T04:15:17.399-07:002016-07-02T04:15:17.399-07:00Hey Vladimir, great blog! I came upon this blog o...Hey Vladimir, great blog! I came upon this blog on glycine while doing some research on a blog of my own and it definitely belonged in the first spot on google search. I like how succinct and heavily referenced it is. I have some additional info for you:<br /><br />One of the major mechanisms by which glycine can affect health is via the conjugation of bile acids. Both glycine and taurine, which you also mention, are required for conjugation of bile acids, which prevents them from destroying cells in the gall bladder and digestive tract. Glycine conjugation is the major pathway in humans and taurine conjugation is the major pathway in rats. <br /><br />An interesting thing to point out here is that glycine synthesis occurs via a few routes, but 2 of the primary ways that don't involve serine involve the methylation process. Specifically, glycine can be made via 5, 10 MTHF which is in the folate cycle and from sarcosine in the choline cycle.<br /><br />It's also interesting to note that bile salts require phosphatidylcholine to prevent mucosal injury. PC is upstream from both choline and glycine in the choline cycle, so adequate choline intake improves glycine synthesis, or more accurately, prevents glycine deficiency. This is probably a bigger issue for people with MTHFR SNPs that may decrease glycine synthesis via that route.<br /><br />On the choline cycle side of things, there is a SNP in the choline dehydrogenase enzyme that decreases the conversion of choline to trimethylglycine which is the step prior to the one that powers methylation. Trimethylglycine(TMG) is just like the name suggests, a glycine with 3 methyl groups. The gradual removal of these 3 methyl groups eventually produces glycine, but if you have the SNP that reduces your ability to make TMG you will also synthesize less glycine via this route.<br /><br />Here's a figure showing this route...<br /><br />http://www.nature.com/ncomms/2016/160129/ncomms10558/fig_tab/ncomms10558_F3.html<br /><br />There's a lot more to it, but I don't want to clog up your comments section. Thanks for the great blog, it was definitely informative.<br />Anonymoushttps://www.blogger.com/profile/14160111478946912124noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-69658057814674499042015-08-15T13:03:56.309-07:002015-08-15T13:03:56.309-07:00Thanks for the great article.Just started using Gl...Thanks for the great article.Just started using Glycine power. Testing it's effects on post-workout inflammation. Playing with daily and post-workout doses. Lower dose morning and higher post training. Too early to tell yet. If you have any suggestions it would be greatly appreciated. <br /><br />Thank you!<br />Anonymoushttps://www.blogger.com/profile/03004595087604078882noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-34204864351979027702015-07-25T11:24:48.157-07:002015-07-25T11:24:48.157-07:00Thank you so much for your mindful aggregation and...Thank you so much for your mindful aggregation and analysis of the available info on glycine ingestion.Anonymoushttps://www.blogger.com/profile/11239537182938519923noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-19716550536144587362015-06-22T10:10:58.861-07:002015-06-22T10:10:58.861-07:00love your material and research ethic
You are p...love your material and research ethic <br /><br />You are providing valuable material <br /><br />I am in NEVADA USA age is 70<br /><br />I like the GLYCINE article and will definite use as supplement<br /><br />THANK YOU<br /><br /> Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-34142443777101015332015-06-19T06:27:05.696-07:002015-06-19T06:27:05.696-07:00Tea is not a wonder cure-all like many health clai...Tea is not a wonder cure-all like many health claims out there try to boast. It has been said to help everything from a cold to cancer. And while most studies are very promising about its benefits, you'll find conflicting studies as well.<a href="http://toenailfungi.org/product-reviews/moraz-skin-care-face-lips-products-review/" rel="nofollow">Moraz Skin Care</a> johnhttps://www.blogger.com/profile/17618704117440830547noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-82321469204975281032015-05-30T05:25:59.615-07:002015-05-30T05:25:59.615-07:00Thanks Thanks Imranhttps://www.blogger.com/profile/18006625857680734916noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-34657805771078565552015-05-28T11:37:34.510-07:002015-05-28T11:37:34.510-07:00Hi imran,
Nowadays I don't use gelatin often,...Hi imran,<br /><br />Nowadays I don't use gelatin often, but I used to use Dr. Oetker's "liivatejauhe" (65g; sold in food stores) or Now Foods Beef Gelatin (1 pound; ordered from iHerb).<br /><br />I have also been using glycine powder from Aminopörssi (located in Konala, Helsinki; hey also have a webstore).Vladimir Heiskanen (Valtsu)https://www.blogger.com/profile/15561977841529110781noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-88890307282720985282015-05-28T09:49:04.357-07:002015-05-28T09:49:04.357-07:00Hello,
Which local brand of gelatin you are using...Hello,<br /><br />Which local brand of gelatin you are using? I am living in Helsinki.Imranhttps://www.blogger.com/profile/18006625857680734916noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-87910138027630934052015-03-24T12:00:12.085-07:002015-03-24T12:00:12.085-07:00Hi Kelly,
I'm sorry for a late answer. I just...Hi Kelly,<br /><br />I'm sorry for a late answer. I just didn't notice your message when you posted it...<br /><br />The study you are linking doesn't show that glycine would increase oxalates:<br /><br />"There were no significant changes in the urinary excretion of oxalate, calcium, or citrate. [...] These results provide no biochemical evidence of an increased risk of renal lithiasis due to glycine irrigation during transurethral operations."<br /><br />But I acknowledge that some people seem to have some problems with glycine. I think it should be used with caution, if any symptoms appear.Vladimir Heiskanen (Valtsu)https://www.blogger.com/profile/15561977841529110781noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-77796760010595782522015-02-20T09:19:21.611-08:002015-02-20T09:19:21.611-08:00Glycine isn't without it's negatives. It ...Glycine isn't without it's negatives. It has been shown to increase oxalates, both anecdotally and in studies:<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/8140673<br /><br />And see Ty's posts here:<br /><br />http://180degreehealth.com/glycine-insulin-resistance/<br /><br />???Kellynoreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-10937780477008524002015-02-08T05:51:12.077-08:002015-02-08T05:51:12.077-08:00Oh, btw, my reason for taking glycine is primarily...Oh, btw, my reason for taking glycine is primarily to combat possible inflammation whilst my daughter is focused more on muscle strength and development.Anonymoushttps://www.blogger.com/profile/12019306814070626409noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-50864373467177397912015-02-08T05:40:47.151-08:002015-02-08T05:40:47.151-08:00To anonymous - could you please say more about bot...To anonymous - could you please say more about both glutamate and GABA (what are they, how do they get into our system) and how they react with glycine? It's been interesting that for both my daughter and me taking some glycine at bedtime, far from resulting in more restful sleep, can lead to extreme restlessness and vivid dreams. I'm taking glycine (up to 5g daily) now in the mornings and afternoons to avoid this. Anonymoushttps://www.blogger.com/profile/12019306814070626409noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-64123363661804594092014-07-19T12:38:41.910-07:002014-07-19T12:38:41.910-07:00I think that 2800mg of the powder is the correct a...I think that 2800mg of the powder is the correct answer. It would contain 2400mg of glycine and 400mg of magnesium. :)Vladimir Heiskanen (Valtsu)https://www.blogger.com/profile/15561977841529110781noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-12584987429968991472014-07-17T08:08:33.223-07:002014-07-17T08:08:33.223-07:00"Magnesium (bis)glycinate supplements have 6:..."Magnesium (bis)glycinate supplements have 6:1 ratio of magnesium:glycine, so eating 350mg magnesium (as magnesium glycinate) daily should yield approximately 2 grams of (di)glycine"<br /><br />So your saying when measuring out magnesium glycinate powder we should multiply x 6? For example if I wanted to include 400 mg of magnesiurm from magnesium glycinate that I shouild take 2400 mg of the powder?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-51889474400659019502014-07-10T00:18:56.793-07:002014-07-10T00:18:56.793-07:00Hi,
8g/day is what Joel Brind (Sweetamine) recomm...Hi,<br /><br />8g/day is what Joel Brind (Sweetamine) recommends. I think it's probably a good dose. I'm personally using 2-6 grams of glycine daily and 1 gram of histidine daily.<br /><br />I have noticed that glycine powder has a disgusting taste when you consume high amounts. I usually put my glycine powder into "double 00" capsules (Now Foods).Vladimir Heiskanen (Valtsu)https://www.blogger.com/profile/15561977841529110781noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-91817368081473066702014-07-09T14:46:56.460-07:002014-07-09T14:46:56.460-07:00Do you think that 8g/day would be a good amount fo...Do you think that 8g/day would be a good amount for allowing the intestine to heal? I know I have intestinal permiabilty to some degree because I have very visible feedback on the skin of my hands that corresponds exactly to certian foods I eat. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-63669726325897329862014-07-03T16:29:57.677-07:002014-07-03T16:29:57.677-07:00Hi Anonymous,
Unfortunately, I have _very little_...Hi Anonymous,<br /><br />Unfortunately, I have _very little_ knowledge on glycine's effects on neurons. I hope you find the answers by yourself, because I think that I'm not able to help.<br /><br />Thanks for informing about Yasko's point of view, it sounds quite interesting.<br /><br />So far, two commenters at 180DegreeHealth have mentined that they are getting adverse effects from glycine: http://180degreehealth.com/thyroid-inflammation-metabolic-syndrome-suprising-power-context/<br /><br />Here's one part of my answer on one comment:<br /><br />"What I find interesting that some neurology researchers have been studying “glycine antagonists” for acute treatment of stroke, because they see glycine as an potential cause excitotoxicity.<br /><br />However, it seems that many of “glycine antagonists” have failed, while real glycine seems to have protective effects against stroke<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/11277826 “This glycine antagonist joins the growing list of neuroprotectants that have not shown improved outcomes for patients with acute stroke, despite promising preclinical results.”<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/10629347 Reduced mortality, risk of disability and lipid peroxidation in the glycine treatment groups (low dose)."Vladimir Heiskanen (Valtsu)https://www.blogger.com/profile/15561977841529110781noreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-36655691021687223042014-07-03T06:48:14.735-07:002014-07-03T06:48:14.735-07:00I'm dealing with serious health problems invol...I'm dealing with serious health problems involving glutamate excitotoxicity. GABA agonists are very helpful. Taurine is helpful. Theoretically, it seems that glycine ought to be helpful, too. But glycine has a clear excitatory effect on my brain, making everything much worse.<br /><br />(I also have a terrible reaction to gelatin and bone broth, though it is unclear whether this is due to the glycine or the glutamate -- or both, or something else.)<br /><br />I have been trying to get to the bottom of this for a long time, but it is hard to find anyone talking about this aspect of glycine. The only person I've found is autism researcher Amy Yasko. Here is a summary of her view:<br /><br />"Glycine is a fair-weather friend. If more glutamate is around it will pal up with the glutamate and cause more excitotoxin activity. If more GABA is around it will pal up with GABA and be more calming. My experience is that early on most [autistic] children have more glutamate and do not tolerate high doses of any source of glycine. Over time they are able to tolerate it as the balance between glutamate and GABA is more ideal."<br /><br />I am very interested in your thoughts!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3293839544812203654.post-10162011789078282142014-06-14T16:24:21.641-07:002014-06-14T16:24:21.641-07:00Great information to think about. Thanks. I ende...Great information to think about. Thanks. I ended up here by following the link you posted in the Longecity forums.Anonymousnoreply@blogger.com